Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317719 | 0.89 | KMT2A (0.43) | ALDH1A1KMT2AMEN1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8317101 | 0.88 | L3MBTL1 (0.33) | ALDH1A1NLRP3KMT2AMEN1L3MBTL1 | |
| SCHEMBL8312985 | 0.85 | ALDH1A1 (0.34) | ALDH1A1MAPTNLRP3HTTKMT2A | |
| SCHEMBL8317256 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MAPTNLRP3HTTKMT2A | |
| SCHEMBL8316895 | 0.82 | HSD11B1 (0.33) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL8317855 | 0.81 | KMT2A (0.34) | ALDH1A1MAPTNLRP3HTTKMT2A | |
| SCHEMBL8876261 | 0.81 | KMT2A (0.42) | ALDH1A1MAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL8317735 | 0.81 | SMN1; SMN2 (0.37) | ALDH1A1MAPTNLRP3KMT2AMEN1 | |
| SCHEMBL8318118 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MAPTHTTKMT2AMEN1 | |
| SCHEMBL8313747 | 0.79 | ALDH1A1 (0.35) | ALDH1A1MAPTNLRP3HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |