Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317474 | 0.90 | KMT2A (0.35) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL8313446 | 0.89 | KMT2A (0.37) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL8314379 | 0.89 | DRD1 (0.45) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL8317651 | 0.88 | PIK3CD (0.39) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8313957 | 0.88 | ALDH1A1 (0.33) | ALDH1A1KDM4EKMT2AMEN1NLRP3 | |
| SCHEMBL8318503 | 0.87 | ALDH1A1 (0.34) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL8312985 | 0.83 | ALDH1A1 (0.34) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8317336 | 0.82 | OPRK1 (0.35) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8876386 | 0.81 | CTSS (0.40) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8317180 | 0.81 | CYP3A4 (0.35) | ALDH1A1MAPTKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |