Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 15/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313018 | 0.91 | METAP2 (0.39) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8332841 | 0.83 | METAP2 (0.40) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8315486 | 0.83 | NPC1 (0.39) | TGFBR1METAP2METAP1GRM5KDM4E | |
| SCHEMBL8312863 | 0.82 | MAPT (0.39) | TGFBR1METAP2METAP1GRM5KDM4E | |
| SCHEMBL8315585 | 0.82 | ADRA1A (0.40) | METAP1GRM5KDM4EMAPTHTT | |
| SCHEMBL8314584 | 0.82 | FABP6 (0.37) | TGFBR1MAPK14METAP2METAP1GRM5 | |
| SCHEMBL8311893 | 0.82 | MAOA (0.35) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8315902 | 0.82 | MAOA (0.33) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8316184 | 0.81 | KDM4E (0.37) | METAP1KDM4EALDH1A1MAPTHTT | |
| SCHEMBL8310381 | 0.81 | HTR2B (0.40) | TGFBR1GRM5KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626954-B1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1999-03-17 | — | — | EP | disclosed |
| US-5602152-A | POTASSIUM CHANNEL MODULATOR | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-02-11 | — | — | US | disclosed |