Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313747 | 0.90 | ALDH1A1 (0.35) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8314625 | 0.89 | KMT2A (0.45) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8316437 | 0.89 | MEN1 (0.33) | KMT2AMEN1ALDH1A1KDM4ECYP19A1 | |
| SCHEMBL8313446 | 0.83 | KMT2A (0.37) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317651 | 0.83 | PIK3CD (0.39) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317349 | 0.82 | GAA (0.35) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8318503 | 0.82 | ALDH1A1 (0.34) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317256 | 0.81 | ALDH1A1 (0.39) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8875827 | 0.81 | KMT2A (0.41) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL8317561 | 0.81 | CYP3A4 (0.35) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |