Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311908 | 0.73 | KDM1A (0.37) | HDAC1HDAC2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8313443 | 0.67 | ALDH1A1 (0.54) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL8316926 | 0.67 | NFE2L2 (0.52) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL8315616 | 0.66 | MAPT (0.52) | HDAC1HDAC2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL27258760 | 0.66 | MTNR1A (0.44) | ALDH1A1KDM4ESCN9ASCN10AKDM1A | |
| SCHEMBL3803230 | 0.66 | HDAC1 (0.52) | HDAC1HDAC2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14619953 | 0.66 | HDAC1 (0.52) | HDAC1HDAC2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7757786 | 0.66 | HDAC1 (0.52) | HDAC1HDAC2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2073331 | 0.66 | HDAC1 (0.52) | HDAC1HDAC2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8316629 | 0.66 | RAB9A (0.50) | HDAC1RAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443588-B1 | Condensed thiazole compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5153201-A | Inhibitors of lipoperoxide and lipoxygenase; antiischemic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| EP-0443588-A1 | Condensed thiazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |