Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316880 | 0.87 | HRH3 (0.39) | HTR7HRH3HTR1AHRH1 | |
| SCHEMBL8312632 | 0.84 | ABCB1 (0.47) | CHRM3HTR7HRH3KCNH2HTR1A | |
| SCHEMBL8317603 | 0.84 | HRH3 (0.40) | HRH3OPRM1OPRK1SLC6A2SLC6A4 | |
| SCHEMBL8316992 | 0.81 | HRH3 (0.39) | HTR7HRH3KCNH2HTR1AHRH1 | |
| SCHEMBL8315438 | 0.80 | KCNH2 (0.43) | HRH3KCNH2 | |
| SCHEMBL8312305 | 0.78 | MC4R (0.39) | CHRM3HRH3KCNH2 | |
| SCHEMBL8316861 | 0.78 | HRH3 (0.48) | HTR7HRH3KCNH2HTR1A | |
| SCHEMBL8316497 | 0.78 | MC4R (0.39) | HRH3KCNH2OPRM1OPRK1SLC6A2 | |
| SCHEMBL8313295 | 0.75 | CHRM1 (0.55) | CHRM1CHRM3HTR7 | |
| SCHEMBL9053675 | 0.68 | PARP1 (0.38) | HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |