Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316880 | 0.84 | HRH3 (0.39) | HRH3DRD3SIGMAR1 | |
| SCHEMBL8314770 | 0.84 | CHRM1 (0.40) | HRH3SLC6A2SLC6A4OPRM1OPRK1 | |
| SCHEMBL8316992 | 0.83 | HRH3 (0.39) | HRH3DRD3 | |
| SCHEMBL8316861 | 0.83 | HRH3 (0.48) | HRH3BACE1ACHE | |
| SCHEMBL8312632 | 0.82 | ABCB1 (0.47) | HRH3DRD3BACE1SIGMAR1 | |
| SCHEMBL8315438 | 0.82 | KCNH2 (0.43) | HRH3DRD3BACE1SIGMAR1 | |
| SCHEMBL8316497 | 0.81 | MC4R (0.39) | HRH3DRD3SLC6A2SLC6A4OPRM1 | |
| SCHEMBL8312305 | 0.81 | MC4R (0.39) | HRH3BACE1 | |
| SCHEMBL9053675 | 0.66 | PARP1 (0.38) | DRD3SIGMAR1 | |
| SCHEMBL9054642 | 0.66 | SIGMAR1 (0.39) | DRD3SIGMAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |