Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313957 | 0.90 | ALDH1A1 (0.33) | MEN1KMT2ACYP3A4POLBALDH1A1 | |
| SCHEMBL8317474 | 0.89 | KMT2A (0.35) | MEN1KMT2AALDH1A1NLRP3CYP19A1 | |
| SCHEMBL8317561 | 0.86 | CYP3A4 (0.35) | MEN1KMT2ACYP3A4POLBALDH1A1 | |
| SCHEMBL8317349 | 0.84 | GAA (0.35) | MEN1KMT2APOLBALDH1A1OPRK1 | |
| SCHEMBL9536573 | 0.84 | MEN1 (0.43) | MEN1KMT2APOLBMAPK1OPRK1 | |
| SCHEMBL8314818 | 0.83 | KMT2A (0.37) | MEN1KMT2APOLBMAPK1NLRP3 | |
| SCHEMBL8317543 | 0.83 | VHL (0.34) | MEN1KMT2ACYP3A4POLBALDH1A1 | |
| SCHEMBL8314625 | 0.82 | KMT2A (0.45) | MEN1KMT2ACYP3A4POLBALDH1A1 | |
| SCHEMBL8316253 | 0.82 | CYP3A4 (0.33) | MEN1KMT2ACYP3A4POLBALDH1A1 | |
| SCHEMBL8313620 | 0.81 | P2RX7 (0.34) | MEN1KMT2ACYP3A4POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |