Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | FAAH | O00519 | 7/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10826240 | 0.86 | MAPT (0.73) | MAPTFAAHABL1POLBRIN1 | |
| SCHEMBL27542336 | 0.82 | MAPK1 (0.55) | MAPTABL1POLBRIN1TDP1 | |
| SCHEMBL27442353 | 0.82 | MAPT (1.00) | MAPTFAAHABL1POLBRIN1 | |
| SCHEMBL6604229 | 0.80 | CACNA1G (0.54) | TDP1MAPK1KDM4EALDH1A1 | |
| SCHEMBL8160104 | 0.80 | HTR1A (0.58) | MAPT | |
| SCHEMBL9634840 | 0.80 | SIGMAR1 (0.61) | MAPTNPSR1KDM4E | |
| SCHEMBL7842690 | 0.79 | OPRM1 (0.45) | MAPTFAAH | |
| SCHEMBL14595398 | 0.79 | FAAH (0.70) | MAPTFAAHNPSR1KDM4EALDH1A1 | |
| SCHEMBL14520829 | 0.78 | ALDH1A1 (0.59) | MAPTTDP1KDM4EALDH1A1 | |
| SCHEMBL11861074 | 0.78 | CYP1A2 (0.53) | POLBTDP1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1136191-C | Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists | ������ҩ������˾ | 2004-01-28 | — | — | CN | disclosed |
| CN-1301253-A | Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists | AVENTIS PHARMACEUTICAL INC (US) | 2001-06-27 | — | — | CN | disclosed |