Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318169 | 0.84 | SLC6A2 (0.34) | MC4RALDH1A1DRD3KCNH2 | |
| SCHEMBL8317987 | 0.83 | ADRA2A (0.36) | ACACBMC4RAADATKDM4EALDH1A1 | |
| SCHEMBL8315238 | 0.82 | P2RX7 (0.33) | P2RX7AADATKDM4E | |
| SCHEMBL8318057 | 0.77 | KDM4E (0.39) | KDM4E | |
| SCHEMBL8316061 | 0.72 | CRY1 (0.35) | KCNH2 | |
| SCHEMBL8314015 | 0.72 | SLC6A2 (0.39) | KDM4EDRD3KCNH2 | |
| SCHEMBL8316696 | 0.68 | SLC6A2 (0.38) | KDM4E | |
| SCHEMBL6985168 | 0.68 | HTR2A (0.40) | KDM4E | |
| SCHEMBL6982495 | 0.67 | KCNH2 (0.32) | KCNH2 | |
| SCHEMBL7081764 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |