Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 17/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318169 | 0.82 | SLC6A2 (0.34) | SLC6A2SLC6A3KCNH2SLC6A4DRD3 | |
| SCHEMBL8318057 | 0.80 | KDM4E (0.39) | SLC6A2SLC6A4KDM4EPKML3MBTL1 | |
| SCHEMBL8316061 | 0.75 | CRY1 (0.35) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL8317987 | 0.74 | ADRA2A (0.36) | KCNH2KDM4EPKML3MBTL1DRD3 | |
| SCHEMBL8317165 | 0.73 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4KDM4EPKM | |
| SCHEMBL8316696 | 0.72 | SLC6A2 (0.38) | SLC6A2SLC6A3SLC6A4KDM4EPKM | |
| SCHEMBL8315724 | 0.72 | P2RX7 (0.35) | KCNH2KDM4EDRD3 | |
| SCHEMBL6985168 | 0.68 | HTR2A (0.40) | KDM4EPKML3MBTL1 | |
| SCHEMBL6982495 | 0.68 | KCNH2 (0.32) | KCNH2 | |
| SCHEMBL6984197 | 0.67 | KDM4E (0.41) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |