Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7556949 | 0.88 | CHRM4 (0.61) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL9531918 | 0.85 | L3MBTL1 (0.54) | SMN1; SMN2CHRM4NPC1RAB9ADRD2 | |
| SCHEMBL8315425 | 0.85 | OPRD1 (0.54) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL15379133 | 0.84 | NOS2 (0.54) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL8696969 | 0.84 | RORC (0.58) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL16936275 | 0.84 | CCR1 (0.64) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL19458995 | 0.84 | ACE2 (0.56) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL751049 | 0.83 | OPRD1 (0.53) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL7676544 | 0.82 | NOS2 (0.49) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL8313841 | 0.82 | CCR1 (0.54) | CCR1SMN1; SMN2MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | claimed |
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |