Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | CRY1 | Q16526 | 4/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 4/20 | 0.34 |
| ▸ | PER2 | O15055 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318662 | 0.88 | DPP8 (0.36) | DPP8DPP9DPP7DPP4CRY1 | |
| SCHEMBL2603740 | 0.80 | KDM4E (0.47) | KDM4ERECQLKCNH2 | |
| SCHEMBL6975709 | 0.79 | PNMT (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8317304 | 0.73 | DPP7 (0.37) | DPP7KCNH2TMEM97SIGMAR1 | |
| SCHEMBL8315757 | 0.72 | CA12 (0.36) | DPP8DPP9DPP7KDM4ERECQL | |
| SCHEMBL6490844 | 0.71 | KDM4E (0.35) | KDM4ERECQL | |
| SCHEMBL8317800 | 0.71 | RYR2 (0.42) | KDM4E | |
| SCHEMBL8317166 | 0.71 | KDM4E (0.39) | DPP8DPP9DPP7KDM4ERECQL | |
| SCHEMBL6490566 | 0.70 | PNMT (0.38) | KDM4ERECQLKCNH2TMEM97SIGMAR1 | |
| SCHEMBL6985370 | 0.70 | NAMPT (0.32) | KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |