Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317719 | 0.89 | KMT2A (0.43) | KMT2ASMN1; SMN2TSHRMEN1GAA | |
| SCHEMBL8318855 | 0.86 | KMT2A (0.40) | KMT2ASMN1; SMN2TSHRMEN1LMNA | |
| SCHEMBL8313570 | 0.86 | ALDH1A1 (0.33) | HSD11B1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL8317101 | 0.84 | L3MBTL1 (0.33) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL8316234 | 0.82 | HSD11B1 (0.33) | HSD11B1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL8316864 | 0.82 | ALDH1A1 (0.38) | KMT2ASMN1; SMN2MEN1LMNAGAA | |
| SCHEMBL8876270 | 0.82 | KMT2A (0.40) | HSD11B1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL8313835 | 0.81 | KMT2A (0.42) | HSD11B1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL8317336 | 0.80 | OPRK1 (0.35) | KMT2ASMN1; SMN2TSHRMEN1LMNA | |
| SCHEMBL8318132 | 0.80 | ABCB1 (0.33) | HSD11B1KMT2ASMN1; SMN2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |