Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316864 | 0.88 | ALDH1A1 (0.38) | L3MBTL1MEN1KMT2AMAPK1NLRP3 | |
| SCHEMBL8317735 | 0.85 | SMN1; SMN2 (0.37) | L3MBTL1MEN1KMT2ANLRP3SMN1; SMN2 | |
| SCHEMBL8316536 | 0.85 | MEN1 (0.32) | MEN1KMT2AMAPK1NLRP3SMN1; SMN2 | |
| SCHEMBL8316895 | 0.84 | HSD11B1 (0.33) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8313620 | 0.82 | P2RX7 (0.34) | MEN1KMT2AMAPK1NLRP3SMN1; SMN2 | |
| SCHEMBL8317719 | 0.82 | KMT2A (0.43) | L3MBTL1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8314373 | 0.81 | MEN1 (0.32) | MEN1KMT2AMAPK1NLRP3SMN1; SMN2 | |
| SCHEMBL8877801 | 0.81 | KMT2A (0.36) | L3MBTL1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL8315905 | 0.81 | ALDH1A1 (0.40) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8313957 | 0.79 | ALDH1A1 (0.33) | MEN1KMT2AMAPK1NLRP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |