Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CDKN1A | P38936 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323865 | 0.78 | KCNMA1 (0.48) | MAPTPOLBTDP1KMT2AMEN1 | |
| SCHEMBL8321734 | 0.78 | PDE4D (0.55) | — | |
| SCHEMBL8319163 | 0.72 | ALDH1A1 (0.39) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8320953 | 0.71 | ALDH1A1 (0.39) | MAPTKMT2AMEN1RECQLSMN1; SMN2 | |
| SCHEMBL3424668 | 0.70 | MAPT (0.50) | MAPTTDP1ALDH1A1HTTGAA | |
| SCHEMBL3427457 | 0.67 | ALDH1A1 (0.50) | MAPTTDP1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7681848 | 0.67 | MEN1 (0.41) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL72916 | 0.66 | KDM4E (0.50) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL9576976 | 0.65 | HMGCR (0.47) | MAPTPOLBTDP1KMT2AMEN1 | |
| SCHEMBL8295144 | 0.65 | ADRA1A (0.45) | POLBTDP1KMT2AFLT3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |