Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10639140 | 0.84 | DRD2 (0.58) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL8317710 | 0.84 | VCAM1 (0.37) | HTR1ADRD2DRD1 | |
| SCHEMBL8315422 | 0.83 | HTR1A (0.53) | HTR1AHTR7HTR1DDRD2CYP1A2 | |
| SCHEMBL9862321 | 0.76 | DRD2 (0.71) | HTR1AHTR7HTR1DDRD2CYP1A2 | |
| Hydrochloric Acid SCHEMBL9424658 | 0.75 | LMNA (0.72) | HTR1AHTR7HTR1DDRD2CYP1A2 | |
| SCHEMBL8315435 | 0.72 | HTR1A (0.71) | HTR1AHTR7HTR1DDRD2CYP1A2 | |
| SCHEMBL8783307 | 0.71 | DRD2 (0.58) | HTR1AHTR7HTR1DDRD2CYP1A2 | |
| Bromide SCHEMBL9449301 | 0.70 | DRD2 (0.56) | HTR1AHTR7HTR1DDRD2CYP1A2 | |
| SCHEMBL10894722 | 0.70 | DRD2 (0.63) | HTR1AHTR1DDRD2DRD1DRD4 | |
| Bromide SCHEMBL10894914 | 0.70 | DRD2 (0.66) | HTR1AHTR7DRD2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |