Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | DRD1 | P21728 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631076 | 0.88 | DRD2 (0.36) | DRD2DRD1OPRM1HTR1A | |
| SCHEMBL8311336 | 0.85 | HTR2A (0.43) | DRD2HTR1A | |
| SCHEMBL8318446 | 0.84 | HTR1A (0.48) | DRD2DRD1HTR1A | |
| SCHEMBL8312041 | 0.77 | HTR1A (0.51) | ALDH1A1DRD2HTR1A | |
| SCHEMBL7445601 | 0.76 | DRD2 (0.42) | DRD2DRD1HTR1A | |
| SCHEMBL12640603 | 0.72 | HTR1A (0.43) | ALDH1A1DRD2HTR1A | |
| SCHEMBL8318624 | 0.71 | HTR1A (0.44) | DRD2HTR1A | |
| SCHEMBL10639140 | 0.70 | DRD2 (0.58) | DRD2HTR1A | |
| SCHEMBL7433347 | 0.69 | PNMT (0.47) | — | |
| Hydrochloric Acid SCHEMBL8632206 | 0.69 | LMNA (0.37) | DRD2OPRM1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |