Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13479959 | 1.00 | ACHE (0.53) | ACHEHSD11B1EPHX2MMP2MMP9 | |
| SCHEMBL8326181 | 0.89 | MMP8 (0.52) | EPHX2MMP2MMP9MMP12MEN1 | |
| SCHEMBL13480219 | 0.87 | ACHE (0.56) | ACHEHSD11B1EPHX2LMNAGAA | |
| SCHEMBL8326043 | 0.87 | ACHE (0.56) | ACHEHSD11B1EPHX2LMNAGAA | |
| SCHEMBL8324754 | 0.87 | MMP2 (0.48) | EPHX2MMP2MMP9MMP12 | |
| SCHEMBL2963202 | 0.87 | MMP2 (0.48) | EPHX2MMP2MMP9MMP12 | |
| SCHEMBL13201315 | 0.86 | MMP2 (0.46) | EPHX2MMP2MMP9MMP12 | |
| SCHEMBL13201339 | 0.85 | MMP2 (0.46) | MMP2MMP9MMP12GAAALDH1A1 | |
| SCHEMBL8324756 | 0.85 | MMP2 (0.46) | MMP2MMP9MMP12GAAALDH1A1 | |
| SCHEMBL8319091 | 0.85 | MMP9 (0.46) | MMP2MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |