Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321916 | 0.92 | SCN4A (0.43) | SCN9ASCN4ANPC1RAB9AMAPT | |
| SCHEMBL8313399 | 0.89 | SCN9A (0.37) | SCN9ASCN4ANPC1RAB9AMAPT | |
| SCHEMBL8321036 | 0.89 | SCN9A (0.40) | SCN9ASCN4ANPC1RAB9AMAPT | |
| SCHEMBL6229769 | 0.83 | MMP9 (0.55) | MMP3MMP9MMP8MMP1MMP14 | |
| SCHEMBL6206247 | 0.78 | SCN4A (0.43) | SCN9ASCN4ANPC1RAB9AMAPT | |
| SCHEMBL6701004 | 0.75 | SCN9A (0.41) | SCN9ASCN4ANPC1RAB9AMAPT | |
| SCHEMBL8320969 | 0.74 | MMP13 (0.56) | MAPTMMP3MMP9MMP8MMP1 | |
| SCHEMBL8313312 | 0.72 | RORC (0.39) | NPC1RAB9ASMN1; SMN2MMP3MMP9 | |
| SCHEMBL8313531 | 0.70 | MMP9 (0.49) | MMP3MMP9MMP8MMP1MMP14 | |
| SCHEMBL8316327 | 0.70 | MMP2 (0.36) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048368-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |