Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2960613 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1POLBKIF11 | |
| SCHEMBL2960166 | 0.87 | HSD17B10 (0.46) | ALDH1A1KMT2AMEN1POLBATM | |
| SCHEMBL8319058 | 0.87 | HSD17B10 (0.46) | ALDH1A1KMT2AMEN1POLBATM | |
| SCHEMBL8319435 | 0.85 | MMP2 (0.48) | ALDH1A1ATMMMP2MMP9MMP12 | |
| SCHEMBL3149439 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1POLBKIF11 | |
| SCHEMBL2969347 | 0.84 | LMNA (0.53) | ALDH1A1KMT2AMEN1POLBATM | |
| SCHEMBL13201300 | 0.84 | LMNA (0.53) | ALDH1A1KMT2AMEN1POLBATM | |
| SCHEMBL2964063 | 0.84 | PSEN1 (0.43) | ALDH1A1KMT2AMEN1POLBATM | |
| SCHEMBL8320723 | 0.84 | PSEN1 (0.43) | ALDH1A1KMT2AMEN1POLBATM | |
| SCHEMBL13201289 | 0.83 | POLB (0.62) | ALDH1A1KMT2AMEN1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| EP-1585728-B1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-02-24 | — | — | EP | disclosed |