Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | MAX | P61244 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.33 |
| ▸ | IGFBP3 | P17936 | 5/20 | 0.33 |
| ▸ | IGFBP5 | P24593 | 3/20 | 0.33 |
| ▸ | CDC42 | P60953 | 2/20 | 0.33 |
| ▸ | RAC1 | P63000 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107294 | 0.80 | PTPN22 (0.38) | EGFRPDGFRBPDGFRAMYCMAX | |
| SCHEMBL9979779 | 0.75 | EGFR (0.42) | EGFRPDGFRBPDGFRAMYCMAX | |
| SCHEMBL15119518 | 0.69 | ALDH1A1 (0.56) | HSD17B10CYP1A2TRPM4MAPTALDH1A1 | |
| SCHEMBL8317211 | 0.68 | NQO2 (0.48) | PDGFRBPDGFRAMAPTALDH1A1 | |
| SCHEMBL9979780 | 0.67 | MAPT (0.46) | EGFRPDGFRBPDGFRAMYCMAX | |
| SCHEMBL9979789 | 0.66 | EGFR (0.36) | EGFRPDGFRBPDGFRAMYCMAX | |
| SCHEMBL888299 | 0.66 | ALDH1A1 (0.68) | HSD17B10CYP1A2CYP2C9TRPM4MAPT | |
| SCHEMBL13719103 | 0.64 | ESR2 (0.51) | MYCMAXHSD17B10CYP1A2CASP1 | |
| SCHEMBL7793886 | 0.64 | CDC42 (0.55) | HSD17B10CYP1A2CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9319235 | 0.64 | MGAM (0.55) | HSD17B10ALOX15IGFBP3IGFBP5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981541-A | ACRIDINE DERIVATIVES; ANTICANCER AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-11-09 | — | — | US | claimed |
| US-5981541-A | ACRIDINE DERIVATIVES; ANTICANCER AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0950054-A1 | SUBSTITUTED HETEROCYCLES AS ANTI-TUMOR AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998012181-A1 | SUBSTITUTED HETEROCYCLES AS ANTI-TUMOR AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1998-03-26 | — | — | WO | disclosed |