Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PYGM | P11217 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HK1 | P19367 | 2/20 | 0.33 |
| ▸ | HK2 | P52789 | 2/20 | 0.33 |
| ▸ | CDA | P32320 | 2/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6907428 | 0.79 | LMNA (0.43) | KMT2AHPGDMAPT | |
| Allopurinol SCHEMBL1144826 | 0.76 | SMN1; SMN2 (0.60) | PNPMEN1KMT2APAX8HK1 | |
| Xanthine SCHEMBL11134143 | 0.74 | ACHE (0.59) | PNPMEN1KMT2APYGMPAX8 | |
| Xanthine SCHEMBL133793 | 0.74 | ACHE (0.59) | PNPMEN1KMT2APYGMPAX8 | |
| Hypoxanthine SCHEMBL9538156 | 0.74 | ALDH1A1 (0.53) | PNPMEN1KMT2APAX8CDA | |
| Ribose (Furanose) SCHEMBL16620262 | 0.71 | PNP (0.44) | PNPMEN1KMT2APYGMPAX8 | |
| SCHEMBL8463341 | 0.71 | KDM4E (0.46) | MAPT | |
| SCHEMBL15284051 | 0.71 | PNP (0.38) | PNPMEN1KMT2A | |
| SCHEMBL6910983 | 0.70 | ADK (0.65) | MEN1KMT2APYGMPAX8HPGD | |
| SCHEMBL6910977 | 0.70 | ADK (0.65) | MEN1KMT2APYGMPAX8HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5864033-A | ENZYME INHIBITORS WITH HETEROCYCLIC BASES | METABASIS THERAPEUTICS, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| EP-0682519-A4 | ADENOSINE KINASE INHIBITORS. | GENSIA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0682519-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994017803-A9 | ADENOSINE KINASE INHIBITORS | — | 1994-09-29 | — | — | WO | disclosed |
| WO-1994017803-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | disclosed |