Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27853405 | 0.83 | ALDH1A1 (0.44) | LMNAHTTPKMRAB9AALDH1A1 | |
| SCHEMBL11167064 | 0.78 | MAOA (0.50) | KIF11RAB9AALDH1A1L3MBTL1SLC6A2 | |
| SCHEMBL8326387 | 0.78 | TAAR1 (0.41) | HTTKIF11ALDH1A1TAAR1PPARG | |
| SCHEMBL1115608 | 0.78 | MAOB (0.46) | ALDH1A1TAAR1MAOASIGMAR1CYP2A6 | |
| SCHEMBL3822095 | 0.77 | GPR52 (0.51) | RAB9AALDH1A1TAAR1MAOASMN1; SMN2 | |
| SCHEMBL8324358 | 0.75 | TAAR1 (0.43) | KIF11SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL8326302 | 0.75 | HTR2A (0.41) | KIF11 | |
| SCHEMBL8464288 | 0.75 | CYSLTR2 (0.48) | LMNAKIF11RAB9ASLC6A2SLC6A4 | |
| SCHEMBL16105692 | 0.74 | AHR (0.52) | HTTALDH1A1MAOACYP3A4SMN1; SMN2 | |
| SCHEMBL16105818 | 0.74 | AHR (0.52) | HTTALDH1A1MAOACYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |