Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324318 | 0.82 | TAAR1 (0.44) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8322028 | 0.82 | TAAR1 (0.44) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8324959 | 0.82 | SIGMAR1 (0.39) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8330718 | 0.81 | NFE2L2 (0.49) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8323856 | 0.81 | MAOA (0.49) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8319052 | 0.81 | PNMT (0.49) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8320387 | 0.77 | HTR2A (0.53) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL8322751 | 0.75 | LMNA (0.37) | TAAR1SLC6A2SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL14157350 | 0.75 | TYR (0.42) | SIGMAR1CACNA1CKIF11 | |
| SCHEMBL8326387 | 0.73 | TAAR1 (0.41) | TAAR1HTR2AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |