Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328152 | 0.89 | RIPK1 (0.38) | RIPK1PRKCATP53MAPTNPC1 | |
| SCHEMBL8328262 | 0.87 | HDAC3 (0.40) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL8329333 | 0.85 | KDM1A (0.40) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL8330600 | 0.84 | KDM1A (0.39) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL8328376 | 0.76 | CASP3 (0.40) | HDAC3HDAC1HDAC2NCOR2BACE1 | |
| SCHEMBL8327226 | 0.76 | HDAC3 (0.41) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL8328009 | 0.75 | ADRB2 (0.44) | RIPK1TP53MAPTNPC1CASP3 | |
| SCHEMBL19545290 | 0.75 | HDAC3 (0.40) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL2892096 | 0.73 | HDAC3 (0.45) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL4744310 | 0.72 | SSTR4 (0.56) | KDM1AHDAC8HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |