Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CPN1 | P15169 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322584 | 0.82 | MAOA (0.49) | MAOAMAOBCYP19A1NPSR1NPC1 | |
| SCHEMBL8324378 | 0.82 | SCN4A (0.44) | SCN4ANPC1TACR1 | |
| SCHEMBL8321946 | 0.82 | NFE2L2 (0.49) | NPC1CYP3A4 | |
| SCHEMBL8324064 | 0.82 | SCN4A (0.44) | MAOBSCN4ANPC1TACR1 | |
| SCHEMBL8326302 | 0.82 | HTR2A (0.41) | SCN4A | |
| SCHEMBL8322926 | 0.78 | IDO1 (0.52) | NPC1MAPTTACR1 | |
| SCHEMBL8326846 | 0.77 | RELA (0.46) | SCN4ACYP3A4 | |
| SCHEMBL8327108 | 0.72 | NFE2L2 (0.44) | SCN4AMAPTRECQL | |
| SCHEMBL8322049 | 0.72 | TACR1 (0.41) | SCN4ATACR1 | |
| SCHEMBL8326407 | 0.72 | CYP3A4 (0.39) | SCN4ANPC1TACR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |