Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 5/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323194 | 0.82 | MAOA (0.50) | SCN4ATACR1NPC1MAOB | |
| SCHEMBL8328586 | 0.81 | ALDH1A1 (0.46) | GRIK1GRIK2IDO1TDO2CHRM5 | |
| SCHEMBL8321946 | 0.81 | NFE2L2 (0.49) | IDO1TDO2CHRM5NPC1RAB9A | |
| SCHEMBL8326302 | 0.81 | HTR2A (0.41) | SCN4A | |
| SCHEMBL8324378 | 0.81 | SCN4A (0.44) | SCN4ATACR1NPC1 | |
| SCHEMBL8326407 | 0.80 | CYP3A4 (0.39) | SCN4ATACR1NPC1RAB9A | |
| SCHEMBL8322926 | 0.77 | IDO1 (0.52) | TACR1IDO1TDO2GRIN1GRIN2B | |
| SCHEMBL8326846 | 0.75 | RELA (0.46) | SCN4AGRIK1GRIK2GRIN1GRIN2B | |
| SCHEMBL16957527 | 0.74 | CHRM5 (0.47) | GRIK1GRIK2CHRM5GRIN1GRIN2B | |
| SCHEMBL16950868 | 0.71 | TSHR (0.45) | GRIK1GRIK2CHRM5GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |