Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328986 | 0.81 | HTR2A (0.42) | ALDH1A1KMT2AMEN1POLBLMNA | |
| SCHEMBL8327931 | 0.79 | NR1H2 (0.35) | ALDH1A1KMT2AMEN1POLBLMNA | |
| SCHEMBL3156042 | 0.76 | HTR2A (0.46) | SMN1; SMN2SIGMAR1HTR2AHTR2C | |
| SCHEMBL8330362 | 0.73 | HTR2A (0.38) | ALDH1A1KMT2AMEN1RAB9AHTR2A | |
| SCHEMBL8329532 | 0.69 | SIGMAR1 (0.41) | ALDH1A1SIGMAR1HTR2AHTR2C | |
| SCHEMBL8320925 | 0.68 | HTR2A (0.42) | ALDH1A1KMT2AMEN1POLBLMNA | |
| SCHEMBL8327015 | 0.68 | CYP11B2 (0.53) | SIGMAR1 | |
| SCHEMBL8324980 | 0.67 | HTR2A (0.42) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL22617009 | 0.67 | KMT2A (0.69) | ALDH1A1KMT2AMEN1POLBLMNA | |
| SCHEMBL29329047 | 0.66 | CYP4F2 (0.49) | ALDH1A1KMT2AMEN1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |