Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324902 | 0.84 | MAOB (0.49) | TAAR1SLC6A2CYP3A4CYP2D6NPC1 | |
| SCHEMBL8324690 | 0.83 | TAAR1 (0.46) | TAAR1SLC6A2CYP2D6NPC1IDO1 | |
| SCHEMBL8321757 | 0.83 | SLC6A2 (0.48) | NFE2L2TAAR1SLC6A2CYP2D6MAPT | |
| SCHEMBL8321777 | 0.82 | GRIN1 (0.45) | NFE2L2TAAR1SLC6A2MAPK1NPC1 | |
| SCHEMBL8323030 | 0.82 | SLC6A2 (0.44) | TAAR1SLC6A2NPC1CHRM5RAB9A | |
| SCHEMBL8326038 | 0.79 | SLC6A2 (0.42) | TAAR1SLC6A2CYP2D6 | |
| SCHEMBL8323488 | 0.78 | SLC6A2 (0.41) | TAAR1SLC6A2CYP3A4CYP2D6MAPT | |
| SCHEMBL8323216 | 0.77 | SLC6A2 (0.46) | TAAR1SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8323792 | 0.74 | SLC6A2 (0.50) | TAAR1SLC6A2CYP2D6 | |
| SCHEMBL8323288 | 0.74 | TAAR1 (0.46) | TAAR1SLC6A2MAPK1CYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |