Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324902 | 0.79 | MAOB (0.49) | SLC6A2TAAR1LMNACYP3A4CYP2D6 | |
| SCHEMBL8323792 | 0.79 | SLC6A2 (0.50) | SLC6A2TAAR1ALDH1A1LMNAHPGD | |
| SCHEMBL8324690 | 0.78 | TAAR1 (0.46) | SLC6A2TAAR1ALDH1A1LMNACYP2D6 | |
| SCHEMBL8324973 | 0.78 | TRPA1 (0.47) | SLC6A2TAAR1ALDH1A1KDM4ELMNA | |
| SCHEMBL8326038 | 0.78 | SLC6A2 (0.42) | SLC6A2TAAR1LMNACYP2D6SLC6A4 | |
| SCHEMBL8321757 | 0.78 | SLC6A2 (0.48) | SLC6A2TAAR1ALDH1A1LMNACYP2D6 | |
| SCHEMBL27651441 | 0.78 | RELA (0.46) | RELAALDH1A1KDM4EPPARAL3MBTL1 | |
| SCHEMBL8325974 | 0.77 | NFE2L2 (0.46) | SLC6A2TAAR1RELARAB9ACYP3A4 | |
| SCHEMBL8323030 | 0.77 | SLC6A2 (0.44) | SLC6A2TAAR1ALDH1A1HPGDRAB9A | |
| SCHEMBL8323488 | 0.77 | SLC6A2 (0.41) | SLC6A2TAAR1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |