Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | MAOA | P21397 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324690 | 0.86 | TAAR1 (0.46) | MAOBMAOASLC6A2TAAR1LMNA | |
| SCHEMBL8323030 | 0.84 | SLC6A2 (0.44) | SLC6A2TAAR1NPC1 | |
| SCHEMBL8325974 | 0.84 | NFE2L2 (0.46) | SLC6A2TAAR1CYP2D6NPC1MAPT | |
| SCHEMBL8326038 | 0.82 | SLC6A2 (0.42) | MAOASLC6A2TAAR1LMNACYP2D6 | |
| SCHEMBL8321777 | 0.82 | GRIN1 (0.45) | MAOBSLC6A2TAAR1NPC1MAPT | |
| SCHEMBL8323216 | 0.79 | SLC6A2 (0.46) | SLC6A2TAAR1LMNACYP2D6MAPT | |
| SCHEMBL8323792 | 0.77 | SLC6A2 (0.50) | SLC6A2TAAR1LMNACYP2D6SMN1; SMN2 | |
| SCHEMBL8321757 | 0.75 | SLC6A2 (0.48) | SLC6A2TAAR1LMNACYP2D6MAPT | |
| SCHEMBL8323488 | 0.75 | SLC6A2 (0.41) | SLC6A2TAAR1LMNACYP2D6MAPT | |
| SCHEMBL8323288 | 0.73 | TAAR1 (0.46) | SLC6A2TAAR1LMNACYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |