Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321757 | 0.85 | SLC6A2 (0.48) | SLC6A2TAAR1KIF11LMNACYP2D6 | |
| SCHEMBL8324690 | 0.82 | TAAR1 (0.46) | SLC6A2TAAR1LMNACYP2D6SMN1; SMN2 | |
| SCHEMBL8323288 | 0.82 | TAAR1 (0.46) | SLC6A2TAAR1KIF11LMNACYP2D6 | |
| SCHEMBL8324973 | 0.82 | TRPA1 (0.47) | SLC6A2TAAR1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8323216 | 0.79 | SLC6A2 (0.46) | SLC6A2TAAR1LMNACYP2D6SMN1; SMN2 | |
| SCHEMBL8324902 | 0.77 | MAOB (0.49) | SLC6A2TAAR1LMNACYP2D6SMN1; SMN2 | |
| SCHEMBL8323030 | 0.74 | SLC6A2 (0.44) | SLC6A2TAAR1KIF11ALDH1A1HPGD | |
| SCHEMBL8325974 | 0.74 | NFE2L2 (0.46) | SLC6A2TAAR1CYP2D6 | |
| SCHEMBL8323488 | 0.74 | SLC6A2 (0.41) | SLC6A2TAAR1KIF11LMNACYP2D6 | |
| SCHEMBL5308339 | 0.73 | SLC6A2 (0.55) | SLC6A2TAAR1KIF11LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |