Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324902 | 0.82 | MAOB (0.49) | SLC6A2TAAR1TRPA1MAOALMNA | |
| SCHEMBL8324690 | 0.81 | TAAR1 (0.46) | SLC6A2TAAR1MAOABACE1LMNA | |
| SCHEMBL8325974 | 0.79 | NFE2L2 (0.46) | SLC6A2TAAR1CYP2D6 | |
| SCHEMBL8323030 | 0.79 | SLC6A2 (0.44) | SLC6A2TAAR1KIF11SLC6A4SLC6A3 | |
| SCHEMBL8323216 | 0.78 | SLC6A2 (0.46) | SLC6A2TAAR1SLC6A4SLC6A3CYP2A6 | |
| SCHEMBL8321777 | 0.77 | GRIN1 (0.45) | SLC6A2TAAR1SMN1; SMN2 | |
| SCHEMBL8324358 | 0.73 | TAAR1 (0.43) | SLC6A2TAAR1KIF11MAOASLC6A4 | |
| SCHEMBL8323792 | 0.72 | SLC6A2 (0.50) | SLC6A2TAAR1KIF11TRPA1BACE1 | |
| SCHEMBL8322751 | 0.71 | LMNA (0.37) | SLC6A2TAAR1KIF11MAOASLC6A4 | |
| SCHEMBL8321757 | 0.71 | SLC6A2 (0.48) | SLC6A2TAAR1KIF11TRPA1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |