Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321757 | 0.84 | SLC6A2 (0.48) | TAAR1SLC6A2GRIN2BLMNAMAPT | |
| SCHEMBL8321777 | 0.84 | GRIN1 (0.45) | TAAR1SLC6A2NPC1RAB9AGRIN2B | |
| SCHEMBL8323792 | 0.82 | SLC6A2 (0.50) | TAAR1SLC6A2LMNAALDH1A1KIF11 | |
| SCHEMBL8324973 | 0.78 | TRPA1 (0.47) | TAAR1SLC6A2LMNAMAPTMAPK1 | |
| SCHEMBL8323216 | 0.75 | SLC6A2 (0.46) | TAAR1SLC6A2RAB9AGRIN2BLMNA | |
| SCHEMBL8325974 | 0.74 | NFE2L2 (0.46) | TAAR1SLC6A2NPC1RAB9AMAPT | |
| SCHEMBL8323488 | 0.74 | SLC6A2 (0.41) | TAAR1SLC6A2GRIN2BLMNAMAPT | |
| SCHEMBL8324902 | 0.73 | MAOB (0.49) | TAAR1SLC6A2NPC1LMNAMAPT | |
| SCHEMBL12913927 | 0.72 | SLC6A2 (0.59) | TAAR1SLC6A2LMNAMAPK1ALDH1A1 | |
| SCHEMBL10068460 | 0.72 | SLC6A2 (0.59) | TAAR1SLC6A2LMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |