Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329541 | 0.89 | HDAC1 (0.43) | KMT2AKDM1APOLBRAD52GFER | |
| SCHEMBL8328970 | 0.86 | PDE4B (0.40) | KMT2AKDM1APOLBRAD52GFER | |
| SCHEMBL8326172 | 0.80 | HDAC3 (0.43) | KMT2APOLBPHLPP2MEN1GAA | |
| SCHEMBL8327227 | 0.74 | PDE4B (0.56) | KMT2AALDH1A1MEN1MAPTGAA | |
| SCHEMBL8324460 | 0.74 | HRH3 (0.41) | KMT2APOLBRAD52MAPTNPSR1 | |
| SCHEMBL8328444 | 0.73 | MAPT (0.42) | KMT2APOLBRAD52MEN1MAPT | |
| SCHEMBL8331716 | 0.73 | MAPT (0.37) | KMT2APOLBRAD52ALDH1A1MEN1 | |
| SCHEMBL8324676 | 0.73 | P2RX3 (0.41) | KMT2APOLBRAD52MAPTP2RX3 | |
| SCHEMBL3782292 | 0.68 | HDAC1 (0.41) | KMT2APOLBALDH1A1PHLPP2MEN1 | |
| SCHEMBL2511107 | 0.67 | KDM4E (0.49) | KMT2APOLBALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |