Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 15/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328970 | 0.86 | PDE4B (0.40) | P2RX3KDM4EPOLBMAPTOPRM1 | |
| SCHEMBL8327738 | 0.84 | MAPT (0.41) | P2RX3PDE10AKDM4EPOLBMAPT | |
| SCHEMBL8330060 | 0.83 | MAPT (0.39) | P2RX3KDM4EPOLBMAPTOPRM1 | |
| SCHEMBL8328444 | 0.82 | MAPT (0.42) | KDM4EPOLBMAPTOPRM1OPRD1 | |
| SCHEMBL8324460 | 0.81 | HRH3 (0.41) | KDM4EPOLBMAPTOPRM1OPRD1 | |
| SCHEMBL8331716 | 0.80 | MAPT (0.37) | KDM4EPOLBMAPTOPRM1OPRD1 | |
| SCHEMBL8329541 | 0.79 | HDAC1 (0.43) | P2RX3POLBMAPTRAD52KMT2A | |
| SCHEMBL8324672 | 0.79 | MAPT (0.52) | MAPTL3MBTL1 | |
| SCHEMBL8327174 | 0.78 | P2RX3 (0.43) | P2RX3 | |
| SCHEMBL8328465 | 0.78 | PTGS2 (0.40) | P2RX3PDE10AKDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |