Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328970 | 0.93 | PDE4B (0.40) | HDAC1HDAC6HDAC3APPACHE | |
| SCHEMBL8326172 | 0.91 | HDAC3 (0.43) | HDAC1HDAC6HDAC3APPACHE | |
| SCHEMBL8327229 | 0.89 | KMT2A (0.41) | HDAC1HDAC6KMT2AKDM1APOLB | |
| SCHEMBL8330060 | 0.82 | MAPT (0.39) | KMT2APOLBRAD52MAPTMEN1 | |
| SCHEMBL8328444 | 0.80 | MAPT (0.42) | HDAC1HDAC6HDAC3APPACHE | |
| SCHEMBL8324460 | 0.80 | HRH3 (0.41) | HDAC6KMT2APOLBRAD52MAPT | |
| SCHEMBL8331716 | 0.79 | MAPT (0.37) | KMT2APOLBRAD52ALDH1A1MAPT | |
| SCHEMBL8324676 | 0.79 | P2RX3 (0.41) | KMT2APOLBRAD52MAPTP2RX3 | |
| SCHEMBL8324824 | 0.76 | GAA (0.50) | HDAC1HDAC6HDAC3APPACHE | |
| SCHEMBL8329323 | 0.73 | GAA (0.47) | KMT2AALDH1A1MAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |