Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328934 | 0.90 | CHRM1 (0.47) | ICMTPOLBF2RL3CHRM1 | |
| SCHEMBL8327497 | 0.86 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL8413697 | 0.83 | AGTR1 (0.53) | F2RL3AGTR1AGTR2HDAC10HDAC6 | |
| SCHEMBL8329353 | 0.81 | ICMT (0.43) | ICMTAGTR1AGTR2CHRM1 | |
| SCHEMBL8324163 | 0.81 | ICMT (0.45) | ICMTPOLBF2RL3AGTR1AGTR2 | |
| SCHEMBL8329222 | 0.79 | ICMT (0.42) | ICMTAGTR1AGTR2CHRM1 | |
| SCHEMBL8327081 | 0.78 | ICMT (0.43) | ICMTHDAC6 | |
| SCHEMBL8325773 | 0.77 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL8327103 | 0.77 | ESR1 (0.40) | ICMTAGTR1AGTR2HDAC6 | |
| SCHEMBL237890 | 0.76 | RARB (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498721-B1 | N-substituted quinoline derivatives, process for their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1999-12-22 | — | — | EP | claimed |