SCHEMBL8328384

SCHEMBL8328384

O=C(CC(=O)C1CC1)c1cccnc1C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.45
ELANE P08246 2/20 0.45
ACKR3 P25106 3/20 0.42
HCRTR1 O43613 3/20 0.41
HCRTR2 O43614 3/20 0.41
CTNNB1 P35222 1/20 0.40
WNT3A P56704 1/20 0.40
SSTR4 P31391 2/20 0.38
CD38 P28907 1/20 0.36
CYP3A4 P08684 2/20 0.35
HSD11B1 P28845 2/20 0.34
MEN1 O00255 1/20 0.34
GMNN O75496 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
TTR P02766 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
PKM P14618 1/20 0.34
NFKB1 P19838 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL124303 0.81 MGLL (0.43) HDAC6ELANEACKR3HCRTR1HCRTR2
SCHEMBL8439117 0.80 HDAC6 (0.47) HDAC6ELANEACKR3HCRTR1HCRTR2
SCHEMBL8327485 0.77 CTNNB1 (0.50) CTNNB1WNT3ALMNACYP2C9PTGS1
SCHEMBL16787536 0.76 HDAC6 (0.48) HDAC6ELANEHCRTR1HCRTR2CTNNB1
SCHEMBL7708463 0.75 RAB9A (0.55) MEN1ALDH1A1KMT2A
Hydrochloric Acid SCHEMBL5052614 0.75 HDAC6 (0.47) HDAC6ELANEHCRTR1HCRTR2CTNNB1
SCHEMBL3583783 0.74 MAPT (0.47) HDAC6HCRTR1HCRTR2CD38CYP3A4
SCHEMBL2149144 0.74 HDAC6 (0.44) HDAC6CYP3A4MEN1GMNNALDH1A1
SCHEMBL27764496 0.73 HDAC6 (0.50) HDAC6ELANEHCRTR1HCRTR2CTNNB1
SCHEMBL29646334 0.73 P2RX7 (0.58) HDAC6ACKR3HCRTR1HCRTR2CD38

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929510-A2 PROCESSES FOR THE PREPARATION OF ARYL-$g(b)-DIKETONES, ARYL-PYRIMIDINE KETONES AND CROP PROTECTION INTERMEDIATES ZENECA LIMITED (GB) 1999-07-21 EP disclosed
US-5925795-A Processes for the preparation of aryl-β-diketones, arylpyrimidine ketones and crop protection intermediates ZENECA LIMITED (GB) 1999-07-20 US disclosed
EP-0927169-A1 4-CYCLOALKYL-5-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL AS CROP PROTECTION AGENTS ZENECA LIMITED (GB) 1999-07-07 EP disclosed
WO-1998011046-A2 PROCESSES FOR THE PREPARATION OF ARYL-β-DIKETONES, ARYL-PYRIMIDINE KETONES AND CROP PROTECTION INTERMEDIATES ZENECA LIMITED (GB) 1998-03-19 WO disclosed
WO-1998011074-A1 4-CYCLOALKYL-5-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL AS CROP PROTECTION AGENTS ZENECA LIMITED (GB) 1998-03-19 WO disclosed
US-5707930-A HERBICIDES, AGRICULTURE ZENECA LIMITED (GB) 1998-01-13 US disclosed