Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 12/20 | 0.38 |
| ▸ | NOS1 | P29475 | 10/20 | 0.36 |
| ▸ | NOS3 | P29474 | 9/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330518 | 0.95 | NOS2 (0.40) | NOS2NOS1NOS3PRKCI | |
| SCHEMBL6164525 | 0.84 | NOS2 (0.39) | NOS2NOS1NOS3TLR8 | |
| SCHEMBL6166695 | 0.84 | NOS2 (0.45) | NOS2NOS1NOS3 | |
| SCHEMBL13040655 | 0.82 | NOS2 (0.38) | NOS2NOS1NOS3TLR8 | |
| SCHEMBL6167004 | 0.82 | NOS2 (0.38) | NOS2NOS1NOS3TLR8 | |
| SCHEMBL13040653 | 0.82 | NOS2 (0.55) | NOS2NOS1NOS3 | |
| SCHEMBL13040656 | 0.82 | NOS2 (0.55) | NOS2NOS1NOS3 | |
| SCHEMBL8330686 | 0.81 | NOS1 (0.57) | NOS2NOS1NOS3 | |
| SCHEMBL8328137 | 0.80 | NOS2 (0.51) | NOS2NOS1NOS3 | |
| SCHEMBL6164330 | 0.79 | RXRA (0.46) | NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |