Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.40 |
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | MMP1 | P03956 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334670 | 0.90 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8332853 | 0.89 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8392500 | 0.89 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8336310 | 0.89 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8340743 | 0.88 | MMP9 (0.40) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8338140 | 0.87 | MMP9 (0.38) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8341075 | 0.86 | NPC1 (0.39) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8340696 | 0.84 | RAB9A (0.46) | KDM4EHTTALDH1A1MAPTLMNA | |
| SCHEMBL8337089 | 0.84 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1HDAC1 | |
| SCHEMBL8339304 | 0.83 | MMP9 (0.42) | MMP9MMP13ADAM17MMP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |