Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059303 | 0.82 | HTR2A (0.40) | HTR2ASMN1; SMN2HTR2C | |
| SCHEMBL7530707 | 0.79 | ALDH1A1 (0.51) | SMN1; SMN2 | |
| SCHEMBL7526020 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2 | |
| SCHEMBL7525330 | 0.75 | ALDH1A1 (0.50) | SMN1; SMN2 | |
| SCHEMBL18893406 | 0.74 | PTGS2 (0.40) | SMN1; SMN2 | |
| SCHEMBL298224 | 0.73 | POLB (0.59) | HTR2AHTR2CTAAR1 | |
| SCHEMBL7248349 | 0.72 | ALDH1A1 (0.36) | SMN1; SMN2 | |
| SCHEMBL5846544 | 0.72 | PGK1 (0.49) | HTR2ASMN1; SMN2HTR2CTAAR1 | |
| SCHEMBL7531918 | 0.71 | MAPT (0.59) | SMN1; SMN2 | |
| SCHEMBL13159618 | 0.71 | ACHE (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101099734-A | Agonism of the 5ht2a receptor for treatment of thermoregulatory dysfunction | WYETH CORP (US) | 2008-01-09 | — | — | CN | claimed |
| CN-1674880-A | 5HT for the treatment of thermoregulatory dysfunction2aAgonism of receptors | WYETH CORP (US) | 2005-09-28 | — | — | CN | claimed |
| CN-106102836-A | Halogen treatment of heart attack and ischemic injury | 弗雷德哈钦森癌症研究中心 | 2016-11-09 | — | — | CN | disclosed |
| CN-101099734-A | Agonism of the 5ht2a receptor for treatment of thermoregulatory dysfunction | WYETH CORP (US) | 2008-01-09 | — | — | CN | disclosed |
| CN-1674880-A | 5HT for the treatment of thermoregulatory dysfunction2aAgonism of receptors | WYETH CORP (US) | 2005-09-28 | — | — | CN | disclosed |
| US-5874477-A | ADMINISTERING AN AMINOTETRALIN, A PHENYL DIOXIN, A AN ERGOLINE, AN INDOLE DERIVATIVE OR AN ALKYLPIPERIDINE, PRECURSORS OF WHICH ARE FRUIT PEELINGS; DISPLACEMENT OF LIGANDS ON SUBTYPE 5HT1A OR 5HT2/5HT1C; REDUCE SYMPTOMS | THE UNIVERSITY OF HAWAII (US) | 1999-02-23 | — | — | US | disclosed |
| WO-1996004898-A1 | A METHOD OF TREATMENT FOR MALARIA | MCCONNELL BRUCE (US) | 1996-02-22 | — | — | WO | disclosed |