Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341968 | 0.78 | NPC1 (0.51) | ADRB2ADRB1ADRB3SMN1; SMN2KDM4E | |
| SCHEMBL3377192 | 0.77 | GAA (0.63) | TP53HTTADRB2ADRB1ADRB3 | |
| SCHEMBL18598078 | 0.76 | PTPN1 (0.49) | TP53HTTADRB2ADRB1ADRB3 | |
| SCHEMBL8335416 | 0.76 | KDM4E (0.47) | ADRB2ADRB1ADRB3PTPN1POLB | |
| SCHEMBL31607663 | 0.74 | PTPN1 (0.53) | HTTCASP3SENP7SENP6PTPN1 | |
| SCHEMBL13036685 | 0.74 | PTPN1 (0.53) | HTTCASP3SENP7SENP6PTPN1 | |
| SCHEMBL8339223 | 0.73 | MAPT (0.51) | PTPN1ERCC5FEN1SMN1; SMN2POLB | |
| SCHEMBL8338779 | 0.71 | ALDH1A1 (0.64) | HTTERCC5FEN1SMN1; SMN2NPC1 | |
| SCHEMBL18329403 | 0.71 | CASP3 (0.43) | ADRB2ADRB1ADRB3CASP3SENP7 | |
| SCHEMBL20508992 | 0.71 | PTPN1 (0.74) | HTTPTPN1ERCC5FEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968975-A | TREATING ATHEROSCLEROSIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1998057925-A1 | ELEVATION OF HDL CHOLESTEROL BY 2-[(AMINOTHIOXOMETHYL)-HYDRAZONO]-2-ARYLETHYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |