Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.42 |
| ▸ | PGK2 | P07205 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346739 | 0.87 | PGK1 (0.44) | PGK1PGK2CYP1A2CYP3A4MAPT | |
| SCHEMBL8942327 | 0.82 | KDM4E (0.38) | CYP1A2CYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL8351298 | 0.76 | KDM4E (0.37) | CYP1A2CYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL8346151 | 0.75 | CYP1A2 (0.32) | CYP1A2CYP3A4MAPT | |
| SCHEMBL8346826 | 0.72 | ADORA2A (0.32) | EGLN1KDM4EALDH1A1HPGD | |
| SCHEMBL8347806 | 0.69 | PGK1 (0.32) | PGK1PGK2 | |
| SCHEMBL1901476 | 0.65 | ALDH1A1 (0.60) | CYP1A2MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL8344080 | 0.65 | LMNA (0.35) | — | |
| SCHEMBL8349215 | 0.64 | SIRT6 (0.33) | — | |
| SCHEMBL15453968 | 0.64 | HTR4 (0.34) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | claimed |
| US-5958904-A | Phosphonomethyl-imidazo 1,2-A! pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury | G.D. SEARLE & CO. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5482933-A | ANOXIA, ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5480876-A | FROM ANOXIA OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |