Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942407 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1HPGDPOLBMAPT | |
| SCHEMBL8346385 | 0.82 | PGK1 (0.42) | KDM4EALDH1A1HPGDMAPTCYP1A2 | |
| SCHEMBL8351298 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1HPGDPOLBMAPT | |
| SCHEMBL8942458 | 0.76 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDMAPTHTT | |
| SCHEMBL8942375 | 0.73 | KDM4E (0.34) | KDM4EALDH1A1HPGDMAPTHTT | |
| SCHEMBL8942378 | 0.70 | DPP4 (0.34) | KDM4EALDH1A1POLBMAPTHTT | |
| SCHEMBL8349330 | 0.70 | KDM4E (0.52) | KDM4EALDH1A1HPGDPOLBMAPT | |
| SCHEMBL8346151 | 0.69 | CYP1A2 (0.32) | MAPTCYP1A2CYP3A4 | |
| SCHEMBL8942328 | 0.69 | PTK2 (0.34) | — | |
| SCHEMBL9602080 | 0.67 | CYP4F2 (0.42) | MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | claimed |
| US-5482933-A | ANOXIA, ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5480876-A | FROM ANOXIA OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |