Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 8/20 | 0.46 |
| ▸ | BRAF | P15056 | 5/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963489 | 0.90 | EGFR (0.44) | DYRK1AEGFRMAPTIGF1RBRAF | |
| SCHEMBL13074426 | 0.87 | DYRK1A (0.44) | DYRK1AEGFRMAPTIGF1RBRAF | |
| SCHEMBL12933411 | 0.86 | EGFR (0.43) | DYRK1AEGFRMAPTIGF1RBRAF | |
| SCHEMBL16677957 | 0.77 | IGF1R (0.56) | EGFRIGF1RBRAFEPHB4CDK2 | |
| SCHEMBL2772290 | 0.75 | LMNA (0.52) | KDM4EMAPTIGF1RKDRAURKA | |
| SCHEMBL12963555 | 0.73 | ACHE (0.46) | KDM4EMAPT | |
| SCHEMBL6977362 | 0.73 | NPC1 (0.54) | EGFRMAPTIGF1REPHB4CDK2 | |
| SCHEMBL1122069 | 0.72 | BRAF (0.69) | BRAF | |
| SCHEMBL2759516 | 0.71 | PTGS2 (0.54) | KDM4EMAPT | |
| SCHEMBL7834331 | 0.71 | LMNA (0.60) | KDM4EMAPTCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |