Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HBB | P68871 | 1/20 | 0.60 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350678 | 0.86 | MMP2 (0.65) | MEN1KMT2ALMNASLC27A1ALDH1A1 | |
| SCHEMBL8351069 | 0.82 | ALDH1A1 (0.58) | NPSR1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL8358063 | 0.78 | THRB (0.66) | THRBNPSR1MEN1KMT2ALMNA | |
| SCHEMBL4008925 | 0.78 | THRB (1.00) | THRBNPSR1MEN1KMT2ALMNA | |
| SCHEMBL4010416 | 0.77 | POLB (0.84) | THRBNPSR1MEN1KMT2ALMNA | |
| SCHEMBL8353194 | 0.76 | ALDH1A1 (0.61) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL5174282 | 0.75 | NPSR1 (0.71) | THRBNPSR1MEN1KMT2ALMNA | |
| SCHEMBL8350094 | 0.74 | POLB (0.59) | MEN1KMT2ALMNAALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL1373101 | 0.74 | NPSR1 (0.69) | THRBNPSR1MEN1KMT2ALMNA | |
| SCHEMBL7008324 | 0.73 | ITGB3 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |