Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 13/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931264 | 1.00 | NOS2 (0.55) | NOS2GRIN2BGRIN1CES1GRIN2D | |
| SCHEMBL17113641 | 1.00 | NOS2 (0.55) | NOS2GRIN2BGRIN1CES1GRIN2D | |
| SCHEMBL18343605 | 0.85 | NOS2 (0.52) | NOS2GRIN2BGRIN1CES1GRIN2D | |
| SCHEMBL18343608 | 0.85 | NOS2 (0.52) | NOS2GRIN2BGRIN1CES1GRIN2D | |
| SCHEMBL29870896 | 0.81 | GRIN1 (0.49) | GRIN2BGRIN1CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2383484 | 0.78 | GRIN2B (0.55) | GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL2371436 | 0.78 | GRIN2B (0.55) | GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL22068857 | 0.76 | NOS2 (0.65) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL22068858 | 0.76 | NOS2 (0.65) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL104888 | 0.76 | NOS2 (0.65) | NOS2GRIN2BGRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515893-B1 | PROCESS FOR PREPARING 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES AND 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIC ACIDS | BAYER CROPSCIENCE AG (DE) | 2020-10-21 | — | — | EP | disclosed |
| US-10556867-B2 | Process for preparing 3-fluoroalkyl-5-pyrazolecarboxylates and 3-fluoroalkyl-5-pyrazolecarboxylic acids | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2020-02-11 | — | — | US | disclosed |
| EP-3515893-A1 | PROCESS FOR PREPARING 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES AND 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIC ACIDS | Bayer CropScience Aktiengesellschaft (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20190225586-A1 | PROCESS FOR PREPARING 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES AND 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIC ACIDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-07-25 | — | — | US | disclosed |
| US-10273215-B2 | Process for preparing substituted pyrazoles containing haloalkoxy- and haloalkylthio groups from alpha,alpha -dihaloalkylamines and ketimines | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-30 | — | — | US | disclosed |
| US-20180186749-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLES CONTAINING HALOALKOXY- AND HALOALKYLTHIO GROUPS FROM alpha,alpha -DIHALOALKYLAMINES AND KETIMINES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-07-05 | — | — | US | disclosed |
| EP-3313820-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLES CONTAINING HALOALKOXY- AND HALOALKYLTHIO GROUPS FROM , -DIHALOALKYLAMINES AND KETIMINES | Bayer CropScience Aktiengesellschaft (DE) | 2018-05-02 | — | — | EP | disclosed |
| WO-2018054807-A1 | PROCESS FOR PREPARING 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES AND 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIC ACIDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-03-29 | — | — | WO | disclosed |
| WO-2016207167-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLES CONTAINING HALOALKOXY- AND HALOALKYLTHIO GROUPS FROM α,α-DIHALOALKYLAMINES AND KETIMINES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-12-29 | — | — | WO | disclosed |
| US-7592316-B2 | Peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592316-B2 | Peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-20070232549-A1 | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION | 2007-10-04 | — | — | US | disclosed |
| US-20070232549-A1 | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION | 2007-10-04 | — | — | US | disclosed |
| US-7244721-B2 | Peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244721-B2 | Peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION (US) | 2007-07-17 | — | — | US | disclosed |
| US-20070032433-A1 | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION CORVAS INTERNATIONAL, LTD. | 2007-02-08 | — | — | US | disclosed |
| US-20070032433-A1 | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION CORVAS INTERNATIONAL, LTD. | 2007-02-08 | — | — | US | disclosed |
| WO-2003062265-A2 | NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS | SCHERING CORPORATION (US) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232549-A1 | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus | HPN, TMPRSS15, VIP | NOS2 3655/4885GRIN2B 4853/4885GRIN1 4799/4885 |
| US-10273215-B2 | Process for preparing substituted pyrazoles containing haloalkoxy- and haloalkylthio groups from alpha,alpha -dihaloalkylamines and ketimines | KMO, KCNK3, HDHD5 | NOS2 4306/4885GRIN2B 2034/4885GRIN1 1706/4885 |
| US-20180186749-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLES CONTAINING HALOALKOXY- AND HALOALKYLTHIO GROUPS FROM alpha,alpha -DIHALOALKYLAMINES AND KETIMINES | KMO, KCNK3, HDHD5 | NOS2 4306/4885GRIN2B 2034/4885GRIN1 1706/4885 |
| US-20190225586-A1 | PROCESS FOR PREPARING 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES AND 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIC ACIDS | KYAT3, PFKFB3, PFKFB1 | NOS2 2987/4885GRIN2B 1684/4885GRIN1 1579/4885 |
| US-20070032433-A1 | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus | HPN, TMPRSS15, VIP | NOS2 3655/4885GRIN2B 4853/4885GRIN1 4799/4885 |
| US-10556867-B2 | Process for preparing 3-fluoroalkyl-5-pyrazolecarboxylates and 3-fluoroalkyl-5-pyrazolecarboxylic acids | KYAT3, PFKFB3, PFKFB1 | NOS2 2987/4885GRIN2B 1684/4885GRIN1 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.