Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357496 | 0.84 | DRD2 (0.53) | NPC1RAB9AMAPTHTTKMT2A | |
| SCHEMBL8552033 | 0.81 | LMNA (0.52) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL8358150 | 0.79 | RAB9A (0.41) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL8355855 | 0.79 | NPC1 (0.45) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL8358033 | 0.77 | MAPT (0.52) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL8357941 | 0.77 | MAPT (0.48) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL8355815 | 0.77 | KMT2A (0.47) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL7595078 | 0.76 | NPC1 (0.61) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL8516569 | 0.74 | MAPT (0.44) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL4692619 | 0.74 | NPC1 (0.57) | NPC1RAB9AMAPTL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919807-A | ANTICHOLESTEROL AGENTS | DR. KARL THOMAE GMBH (DE) | 1999-07-06 | — | — | US | disclosed |